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Non-genetic mechanisms of diabetic nephropathy
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 319-332 doi: 10.1007/s11684-017-0569-9
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus patients and is characterized by thickened glomerular basement membrane, increased extracellular matrix formation, and podocyte loss. These phenomena lead to proteinuria and altered glomerular filtration rate, that is, the rate initially increases but progressively decreases. DN has become the leading cause of end-stage renal disease. Its prevalence shows a rapid growth trend and causes heavy social and economic burden in many countries. However, this disease is multifactorial, and its mechanism is poorly understood due to the complex pathogenesis of DN. In this review, we highlight the new molecular insights about the pathogenesis of DN from the aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrial damage, epigenetics, and podocyte–endothelial communication. This work offers groundwork for understanding the initiation and progression of DN, as well as provides ideas for developing new prevention and treatment measures.
关键词: diabetic nephropathy immune inflammatory response epithelial–mesenchymal transition apoptosis mitochondrial damage epigenetics podocyte–endothelial communication
Effects of resistin on insulin signaling in endothelial cells
Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 136-140 doi: 10.1007/s11684-009-0029-2
关键词: resistin endothelium nitric oxide endothelial nitric oxide synthase Akt-binding protein mouse
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 177-180 doi: 10.1007/s11684-009-0021-x
关键词: vascular endothelial growth factors restenosis reactive oxygen species endothelial cells vascular smooth muscle cell
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 284-286 doi: 10.1007/s11684-009-0062-1
关键词: vascular endothelial growth factor nitric oxide N-nitro-L-arginine methyl ester vascular endothelial cells
Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate
WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen
《医学前沿(英文)》 2007年 第1卷 第4期 页码 356-358 doi: 10.1007/s11684-007-0068-5
关键词: endothelial 16-week treatment leukocyte accumulation mg/kg NO
Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang
《医学前沿(英文)》 2021年 第15卷 第4期 页码 638-643 doi: 10.1007/s11684-021-0831-z
关键词: COVID-19 endothelial dysfunction inflammation reaction cytokine storm
Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction
LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi
《医学前沿(英文)》 2007年 第1卷 第2期 页码 196-199 doi: 10.1007/s11684-007-0037-z
关键词: endothelial resistin stimulation Incubation pathogenesis dysfunction
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
《医学前沿(英文)》 2023年 第17卷 第2期 页码 317-329 doi: 10.1007/s11684-022-0931-4
关键词: lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis
TANG Zhongzhi, LI Junyao, YANG Jianhong
《医学前沿(英文)》 2008年 第2卷 第2期 页码 178-181 doi: 10.1007/s11684-008-0033-y
张乃通,张中兆,初海彬,刘会杰
《中国工程科学》 2002年 第4卷 第10期 页码 11-16
介绍了国际上出现的三种星座通信系统,重点分析了几个具有代表性系统的组成、结构、功能及其存在的问题。探讨了卫星移动通信系统的发展趋势,并对发展卫星移动通信做了几点思考。
邬贺铨
《中国工程科学》 2000年 第2卷 第8期 页码 69-75
文章首先回顾了第一代(模拟)移动通信和第二代(数字)移动通信技术的演进,预测今后10年是移动通信大发展时期,它的用户将超过固定电话用户数。随着因特网的发展,移动通信业务将从话音扩展到数据,移动通信技术也将从电路模式发展到分组模式。文章在简介即将投入应用的第二代半移动通信技术之后,引出面向宽带多媒体应用的第三代移动通信(3GM),重点介绍了被选作3GM国际无线传输技术标准的几种主流方案及其关键技术,特别对其中由我国提交的TD-SCDMA方案的技术特点作了说明,最后展望了网络如何从第二代移动通信过渡到第三代移动通信及3GM核心网发展趋势。
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 204-211 doi: 10.1007/s11684-016-0443-1
CD176 (Thomsen-Friedenreich antigen) is a tumor-associated carbohydrate epitope (glycotope) functionally involved in blood spread and liver metastasis of cancer cells by mediating the adhesion of cancer cells to endothelial cells and hepatocytes, respectively. CD176 could be a promising target for antitumor immunotherapy. We applied B lymphocytes obtained from mice immunized with CD176 antigen and constructed a phage display library. A positive clone of CD176 single-chain variable antibody fragment (scFv) was successfully screened from this library. The CD176 scFv was expressed in Escherichia coli and purified. The purified scFv can bind to the natural CD176 expressed on the surface of cancer cells. Furthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelial cells and hepatocytes. This CD176 scFv provides a basis for future development of recombinant CD176-specific antibodies that can be used in therapeutic application.
关键词: CD176 Thomsen-Friedenreich antigen scFv cancer therapy adhesion metastasis
Special issue on 5G wireless communication systems and technologies Editorial
Ping ZHANG
《信息与电子工程前沿(英文)》 2017年 第18卷 第6期 页码 751-752 doi: 10.1631/FITEE.1720000
关键词: None
姚富强
《中国工程科学》 2005年 第7卷 第5期 页码 24-29
在阐述军事通信抗干扰装备的覆盖范围和分析外军通信抗干扰发展趋势的基础上,结合我军正在进行的新军事变革和信息化建设,重点研究了我军通信抗干扰工程发展策略的有关问题,并提出了一些初步的建议。
标题 作者 时间 类型 操作
Effects of resistin on insulin signaling in endothelial cells
Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU
期刊论文
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
期刊论文
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
期刊论文
Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate
WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen
期刊论文
Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium
Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang
期刊论文
Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction
LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi
期刊论文
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
期刊论文
Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile
TANG Zhongzhi, LI Junyao, YANG Jianhong
期刊论文
CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells
null
期刊论文